Parasite Reveals Mitochondrial Inheritance Machinery
نویسندگان
چکیده
منابع مشابه
Parasite reveals mitochondrial inheritance machinery.
Mitochondria are double membrane bounded organelles that together with the nucleus define the eukaryotic cell. Their main function is energy production by oxidative phosphorylation. Mitochondria derive from bacteria, which during evolution have gradually been converted into organelles. The bacterial descent of mitochondria is reflected by their genome which encodes a small number of essential p...
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The distribution of mitochondria to daughter cells during cell division is an essential feature of cell proliferation. Until recently, it was commonly believed that inheritance of mitochondria and other organelles was a passive process, a consequence of their random diffusion throughout the cytoplasm. A growing recognition of the reticular morphology of mitochondria in many living cells, the as...
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Mitochondria cannot form de novo but require mechanisms that mediate their inheritance to daughter cells. The parasitic protozoan Trypanosoma brucei has a single mitochondrion with a single-unit genome that is physically connected across the two mitochondrial membranes with the basal body of the flagellum. This connection, termed the tripartite attachment complex (TAC), is essential for the seg...
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Gene silencing mediated by dsRNA (RNAi) can persist for multiple generations in Caenorhabditis elegans (termed RNAi inheritance). Here we describe the results of a forward genetic screen in C. elegans that has identified six factors required for RNAi inheritance: GLH-1/VASA, PUP-1/CDE-1, MORC-1, SET-32, and two novel nematode-specific factors that we term here (heritable RNAi defective) HRDE-2 ...
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ژورنال
عنوان ژورنال: CHIMIA International Journal for Chemistry
سال: 2014
ISSN: 0009-4293
DOI: 10.2533/chimia.2014.749